@article {204,
	title = {Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations.},
	journal = {Nature communications},
	volume = {2},
	year = {2011},
	month = {2011},
	pages = {202},
	abstract = {Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-rich blocks comprise one-third of the genome and contain effector genes and families of transposable elements, both of which are affected by repeat-induced point mutation, a fungal-specific genome defence mechanism. This genomic environment for effectors promotes rapid sequence diversification and underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints.},
	keywords = {Ascomycota, Base Composition, Base Sequence, Computational Biology, DNA Transposable Elements, Genetic Variation, Genome, Fungal, Molecular Sequence Annotation, Molecular Sequence Data, Phylogeny, Point Mutation, Sequence Analysis, DNA, Transcription Factors},
	issn = {2041-1723},
	doi = {10.1038/ncomms1189},
	author = {Rouxel, Thierry and Grandaubert, Jonathan and Hane, James K and Claire Hoede and van de Wouw, Angela P and Couloux, Arnaud and Dominguez, Victoria and Anthouard, V{\'e}ronique and Bally, Pascal and Bourras, Salim and Cozijnsen, Anton J and Ciuffetti, Lynda M and Degrave, Alexandre and Dilmaghani, Azita and Duret, Laurent and Fudal, Isabelle and Goodwin, Stephen B and Gout, Lilian and Glaser, Nicolas and Linglin, Juliette and Kema, Gert H J and Lapalu, Nicolas and Lawrence, Christopher B and May, Kim and Meyer, Michel and Ollivier, B{\'e}n{\'e}dicte and Poulain, Julie and Schoch, Conrad L and Adeline Simon and Spatafora, Joseph W and Stachowiak, Anna and Turgeon, B Gillian and Tyler, Brett M and Vincent, Delphine and Weissenbach, Jean and Amselem, Jo{\"e}lle and Hadi Quesneville and Oliver, Richard P and Wincker, Patrick and Balesdent, Marie-H{\'e}l{\`e}ne and Howlett, Barbara J}
}
